Tadalafil (Generic Cialis)
The History Behind Tadalafil’s Approval
The approval of sildenafil in 1998 was the pioneering event for erectile dysfunction treatment with over $1 billion in sales. In 2003, the FDA approved Tadalafil.
ICOS, a biotechnology company originally developed the drug, but it was later redeveloped by Lilly ICOS, LLC, which is a joint venture of the ICOS Corporation and Eli Lilly and company.
It wasn’t until 2009 that Tadalafil was approved in the United States for treating pulmonary arterial hypertension.
What is Tadalafil?
Tadalafil is a phosphodiesterase type 5 inhibitor (PDE5) that increases the flow of blood to the penis and dilates blood vessels in the lungs.
This drug is especially helpful in the treatment of Erectile Dysfunction, benign prostatic hyperplasia (BPH, enlarged prostate), and pulmonary arterial hypertension (PAH, difficulty in the flow of urine, weak stream).
Tadalafil is approved by the FDA for the treatment of erectile dysfunction. In addition, it is also effective in the treatment of lower urinary tract symptoms caused by prostatic hyperplasia.
This drug is also approved by the FDA in enhancing the exercise capability in pulmonary arterial hypertension (PAH) patients.
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The chemical structure of Tadalafil
Tadalafil is usually seen by the user in the form of a tablet but its original form is actually a powder. If you find a leaflet of a drug containing this ingredient, you may sometimes see its chemical structure as C22H19N304. This shows its chemical makeup. But for most patients, this is not something they choose to focus on. However, it can help you identify this ingredient in any medication.
It has a half-life of 17.5 hours which is the longest of all the other alternatives for the treatment of ED.
Trade names: Cialis, Adcirca, Cidala
Drug Bank Accession Number: DB00820
Associated Conditions: Erectile Dysfunction
Protein Binding: 94%
Metabolism: Catechol Metabolite
Elimination Half Life: 17.5 hours
Excretion: Feces, Urine
Molar Mass: 389.411g/mol-1
How does Tadalafil work?
Once it is administered, this drug increases the flow of blood to the penis and relaxes the muscles in the bladder and prostate which helps men in getting and maintaining an erection. The action of Tadalafil on the penis is not automatic. It simply makes it possible for blood to flow to the organ when the man is ready for sex. You need to engage in foreplay to get an erection. The blood will continue to flow for as long as the chemical is in the body.
NB: This drug doesn’t protect against sexually transmitted diseases such as HIV, Syphilis, etc. Practice safe sex and consult with your doctor for more information.
How Tadalafil is Used?
Because different manufacturers may add other ingredients into their drug, it is prudent to read the leaflets to understand the usage of the one you may be using. However, Tadalafil is used in the making of medication to treat ED. Such meds are mainly prescription only because of the possible side effects they can cause. Patients are advised to seek a doctor’s opinion before they begin treatment with any brand medication that contains this ingredient.
Side Effects caused by the use of Tadalafil
Some side effects associated with Tadalafil are; muscle aches, stomach pain, running nose among others.
Muscle aches and back pains occur about 12 to 24 hours after the drug has been administered but the symptoms settle within 48 hours.
Most of the effects are light and can be ignored until they subside. However, there are some severe effects. If you experience any of the following, advanced attention is needed: Chest pain, difficulty breathing, painful erection over 4 hours, any minor effects that persist beyond 6 hours.
Also, vision impairment could be an adverse effect. Although blurred vision is a minor effect, total loss of sight is severe.
Tadalafil should not be taken by a patient using a nitrate drug for heart issues or chest pain. Consumption of this medication with any nitrate drug could result in a serious reduction in blood pressure.
Usually, it is taken once a day with food or without food.
For erectile dysfunction, it is said that Tadalafil takes about 30-60 minutes to work. Also, you need to be aroused sexually for the medication to work as using it on its own is not enough for an erection to kick in.
Always adhere to the directions of your doctor on the prescription.
Who Should Use It?
This medication is intended for adults only. In particular, men with erectile problems can be treated with it. In some cases, women may be treated for pulmonary complications but caution is needed. It is not a recreational drug so if you have a functioning manhood, do not experiment with it.
What Will Happen if You Miss a Dose?
Do not fret nothing bad will happen to you. If taken daily, and you miss a dose, just administer immediately you remember and do not take extra dose to make up for what you missed.
In cases of overdosing, raise an emergency alert and seek medical attention.
Avoid drinking alcohol with this drug as it could lead to a reduction in blood pressure and cause dizziness.
Also, avoid consumption of grapefruit or its juices because it interacts with Tadalafil and could result in unwanted adverse effects.
Is Tadalafil Effective?
Over 6 out of 10 men who have used medication containing this ingredient can testify that they have harder erections. This has gone on to improve different aspects of their life. Even performance at work has been improved after using medicines containing Tadalafil.
There is less stress weighing down on a man when he can satisfy his and his partner’s sexual needs.
The usage of this drug improves a man’s self-esteem, confidence, and sexual relationship satisfaction.
Men who have been treated with Tadalafil experience a boost in self-confidence.
Tadalafil is well tolerated and hugely efficient in men with erectile dysfunction. Also, according to research, patients consuming this drug had significant improvements.
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